Preparations Klenzit-S and Klenzit are a line of drugs intended for the treatment of acne and acne. They are produced by the Indian pharmaceutical company "Glenmark", differ significantly from each other in composition and are intended for use in different clinical situations.
This professional review of preparations prepared by a practicing dermatologist. The information below will allow you to understand which of the preparations of the Klenzit series will be effective in your particular case.
Preparations Klenzit-S and Klenzit: photos
Klenzit and Klenzit C: instructions for use
Composition and release form -
the main active ingredient of the drug is the substance "Adapalen". Adapalen belongs to a new generation of synthetic retinoids (Retreoin and Tazaroten also belong to retinoids). Differin is available in two forms - in the form of a cream or gel for external use:
- Gel Klenzit 0.1% -
contains only one active substance "adapalen", which belongs to the class of retinoids (the effects of adapalene can be found below). Klenzit gel is available in tubes of 15 and 30 g. Released from pharmacies without a prescription.
- Gel Klenzit With -
contains a combination of active substances: the retinoid "adapalen" (0.1%) and the antibiotic clindamycin (1%). Available in tubes of 15 and 30 g. Released in pharmacies only by prescription.
Which drug to choose: indications for use
In the instructions for both drugs it is written that he and the other drug should be used for acne. Actually - this is not entirely correct, because The international classification, unfortunately, does not take into account the difference between acne and acne.
Acne (synonym - comedones) is formed as a result of blockage of the skin pores with fatty secretions secreted by the sebaceous glands, as well as desquamated necrotic epithelial cells. In fact, acne is a fatty plug in the pores of the skin, in the depths of which hair follicles and sebaceous glands are located. Acne may look like -
- either as white bumps on the skin surface (closed comedones, fig.3),
- or as black dots in the pores of the skin (open comedones, fig.4).
Acne is a continuation of the development of acne. Formed in the upper part of the skin pores fat plugs (acne) lead to the fact that the hair follicles and sebaceous glands, located deep in the pores, remain in a confined space. This creates conditions for the reproduction of pathogenic bacteria and suppuration of hair follicles. This is how classic acne is formed (Fig.5). With acne in the skin there is no inflammation and suppuration.
findings: the drug "Klenzit" with retinoid adapalen should be used for classical acne, when there is only acne without acne. But the drug "Klenzit-S" with adapalen and antibiotic - should be used in situations where the skin has both acne and acne.
Pharmacological properties -
Gels "Klenzit-C" and "Klenzit" are used only externally. The effects of drugs are due to the active ingredients that make up the gels: the Klenzit gel contains Retinoid Adapalen, and the Klenzit-C gel contains Adapalen and the antibiotic Clindamycin.
- Retinoid Adapalen -
all retinoids are derivatives of vitamin A. They have a pronounced effect on comedones (acne), and, both open and closed. Retinoids normalize the processes of keratinization of the epithelium of the hair follicle, resulting in a sharp decrease in the number of desquamated epithelial cells in the lumen of the follicle, which, among other things, lead to clogged skin pores.
- antibiotic Clindamycin -
belongs to the group of lincosamides; It is very effective against bacteria that lead to the suppuration of hair follicles (i.e., the formation of acne). When prescribing, cross-resistance should be taken into account: if the bacteria were not sensitive to the antibiotic Lincomycin, then they would not be sensitive to Clindamycin either. In this case, it is necessary to prescribe gels containing an antibiotic of another group, for example, erythromycin.
Klenzit and Klenzit-S - reviews of a dermatologist
1) Gel Klenzit C" -
because it contains both a retinoid and an antibiotic - this drug is a good choice for the treatment of combined skin lesions, i.e. when there are acne and acne at the same time. But in situations where there is only acne, or only acne - we can not recommend it. In particular, acne - the gold standard of treatment all over the world are drugs based on benzoyl peroxide.
2) Klenzit gel -
contains only retinoid (without antibiotic), which makes this drug an excellent choice for the treatment of acne, because retinoids are the most effective way to fight acne today. Alternatives to retinoids in this case can be drugs based on azelaic or salicylic acids, for example, Skinoren-gel.
Methods of use and dosage -
Apply only externally, preventing the ingress of drugs on the mucous membrane of the eyes, oral cavity, red border of the lips. Before using Klenzit-S and Klenzit gels, it is necessary to cleanse the skin well with mild detergents, and then thoroughly dry it. The gel is applied to the affected skin with light rubbing movements, and the gel should be applied strictly evenly.
- Gel Klenzit-S -
processing is carried out only once a day (before bedtime); The course of treatment is from 2 to 4 weeks. Repeated courses of application must also be agreed with the doctor.
- Klenzit gel -
skin treatment is also carried out only once a day (at bedtime). In order to have fewer side effects, it is recommended that you apply the drug every other week for the first 1-2 weeks so that the skin is used to the drug. The course of treatment is at least 3 months, but a good therapeutic effect from the use of the drug will be noticeable after 4-8 weeks. A full course is needed to consolidate the results of therapy for a long time.
Gels Klenzit and Klenzit C: price
It must be said that the cost of these drugs is quite moderate when compared with drugs from European manufacturers. Average price in pharmacies:
- Klenzit gel: the price for a package of 15 g is from 600 rubles, and for a package of 30 g is from 700 rubles.
- Gel Klenzit C: the price for 15 g - from 620 rubles, and for a package of 30 g - from 850 rubles.
Drugs analogues -
- Klenzit gel - analogues "Derive" (India), "Differin" (France).
- Klenzit-S is an analogue of "Deriva-S" (India), and the relative analogue will be "Isotrexin-gel" containing the antibiotic Erythromycin in combination with the retinoid Isotretinoin.
Also, as an indirect analogue of Klenzit-C preparation, it is worth considering a group of combined preparations containing retinoids in combination with benzoyl peroxide (instead of an antibiotic). For example, the drug "Epido" (France). In many cases, such preparations may be preferable.
Contraindications to use -
- in case of hypersensitivity to any of the components of the drug,
- during pregnancy and breastfeeding,
- with caution - with dermatitis or eczema.
Possible side effects -
Redness of the skin at the site of application, as well as flaking of the skin. Less common may be burning, allergic reactions. In case of severe skin irritation, it is necessary either to temporarily stop using the drug, or to temporarily start using it every day, but every other day.
Special instructions -
- Keep in mind that at the very beginning of the use of Klenzit-C and Klenzit gels, a temporary aggravation of acne is possible. This is normal. This effect disappears during treatment. Also keep in mind that you can not apply the gel on damaged skin with abrasions, scratches.
- You also need to keep in mind that retinoids increase skin sensitivity to sunlight. Therefore, if you plan to use any of these gels during periods of pronounced solar activity (spring, summer), then at the time of application you should definitely use sun protection products, in particular, sunscreens with a high level of sun protection.
- When using retinoids, parallel application of cosmetic products with irritating or drying effects (for example, containing alcohol) is also not desirable. At the same time it is necessary to completely eliminate the use of cosmetics based on fat. For acne and acne in general, you can only use cosmetics based on water.
Expiration date and storage conditions -
It is necessary to store the gels in a place protected from light, and at a temperature of from 2 to 25 ° C. Do not freeze preparations. The shelf life of Klenzit and Klenzit-S gels is 3 years. We hope that our article on the topic: Klenzit C from acne reviews - proved to be useful to you!
Author: editors of the portal.